Class of new-style accept rice is fiber-optic stress sensor: Use at element and cellular level machine to explore
[introduction] the foundation of most biology course is distinctive Namisheng material resources learns incident, conduce to drive reaction and directive and chemical way. These small active force clew may be very delicate and dog hard, but they are the complex share that the environment is answered and maintains life. As the ceaseless development that exceeds instrument of stress of acute accept rice, outside body observe inside body even, measure and operate processes of these active force forehead are one lasts all the time target, so that more comprehensive ground understands unripe material resources,learn a phenomenon.
System of graph 1 NOFT is summarized. A, overcome what law can use at imitate NOFT platform to answer why. As filmy compression, polymer wraps the scattering intensity of the bedspring constant of the layer and NP to increase. B, the overall work flow of preparation NOFT device: SnO2 wave guide is synthesized; The generation of compressible polymer implant; Of grain of golden accept rice adherent; Far field is become picture, data is collected and analyse
Current, obtain likely mix to older cellular structure from single element real time information of the organization. However, as a result of force feedback mechanism and active component, the dimension of sensor of machinery of contractible accept rice still has challenge sex. Have compact force transducer to be able to make a lot of measure get coming true, include monitor inside the cell, small achieve explore and high resolution detects. Below good case, sensor is enough small change in order to make inflammation reaction the least, have at the same time high resolution and dog at the same time the ability of many mechanical incident. With dimension likewise important is mode is operated and detect in order to differ the ability that the Namilite of all sorts of types asks for. For example, in direct contact mode falls, action of enough response of sensor aux will be able to is in the small force on its, but, having blame contact pattern also is advantageous, among them sensor detects the signal of the sound wave and so on that such as comes from bulk change or mobile quality. For this, must design sensor what produce level of prep above noise with sound wave interaction to be able to detect signal. These are new-style the implementation need new method that exceeds acute force transducer and innovation project. At present need development has expensive space resolution and force resolution and can be in all sorts of biology environments the oversoul of the operation instrument of machinery of quick accept rice.
Graph 2 use at detecting the NOFT operation of signal of accept rice machinery. A, the setting is detect the general sketch map of the NOFT system when mechanical or acoustics feature. The Fu Lixie of the scattering signal that the data processing of acoustical signal incorporates to collect alternates (FT) . B, in average signal (variance coefficient) go up of the average scattering signal of the NOTF device of scattering signal and existence or nonexistent bacterium than. C, the FT of the smooth scattering signal of the NOFT device that comes from existence and cell of nonexistent cardiac muscle
Recently, the scientist of university of California university Santiago puts forward a kind to have inferior of sensitivity of leather Newton force and accept rice measure compact model accept rice sensor of fibre optics stress (NOFT) , levelled to explore the complex and mechanical phenomenon inside biology element system road. NOFT platform includes staple of SnO2 accept rice fiber-optic, its match stock fill to have particle of plasma accept rice (the thin, compressible polymer of NPs) wraps a layer. This kind of combination allows what through dogging the optical scattering when NP and fiber-optic near field interaction quantifies NP dust class moves. Once the mechanical function of compressible bag layer is complete token, can change the smooth signal related the distance for force. In this agreement, described the synthesis of NOFT system, the detail of token and calibration. From accept rice the synthesis of fibre optics parts of an apparatus arrives the overall agreement that gets data of accept rice stress needs 72 hours. Relevant content with ” Nanoscale Fiber-optic Force Sensors For Mechanical Probing At Themolecular And Cellular Level ” for the problem, publish in ” Nature Protocols ” on the magazine.
Graph of scattering of 3 near field and particle of golden accept rice adherent. A, the normalization scattering strength that experimental data shows particle of rice of individual gold accept and use assemble oneself get together the WG-NP of electrolyte layer is detached. B, pursue on: Adherent after the deposit on fiber of SnO2 accept rice NP reference and transmission electron microscope (TEM) the sketch map of image. Lay a plan: The sketch map that NP sensor adheres to and the TEM image after the deposit on fiber of SnO2 accept rice